Hook R H, Eastwood C J, Wright G J
Drug Metab Rev. 1975;4(2):249-65. doi: 10.3109/03602537508993759.
Plasma levels of oxyphenbutazone were measured in beagle dogs following oral administration of oxyphenbutazone and salts of oxyphenbutazone phosphate. Dosage with sodium and calcium salts of oxyphenbutazone phosphate produced higher oxyphenbutazone plasma levels than dosage with oxyphenbutazone itself. Oxyphenbutazone phosphate was not detected in plasma following oral dosing with salts of oxyphenbutazone phosphate but was found in plasma following intramuscular administration of oxyphenbutazone phosphate sodium salt. A metabolite, oxyphenbutazone glucuronide, was found in plasma of dogs following administration of either oxyphenbutazone or salts of oxyphenbutazone phosphate.
在比格犬口服奥昔芬布宗及其磷酸奥昔芬布宗盐后，测定其血浆中奥昔芬布宗的水平。给予磷酸奥昔芬布宗的钠盐和钙盐后，血浆中奥昔芬布宗的水平高于给予奥昔芬布宗本身。口服磷酸奥昔芬布宗盐后，血浆中未检测到磷酸奥昔芬布宗，但肌肉注射磷酸奥昔芬布宗钠盐后，血浆中发现了该物质。给予奥昔芬布宗或磷酸奥昔芬布宗盐后，在犬的血浆中发现了一种代谢产物——奥昔芬布宗葡萄糖醛酸苷。
