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[四氯化碳和异种抗肝血清治疗后肝脏再生的放射自显影研究]

[Autoradiographic study of liver regeneration after treatment with carbon tetrachloride and heterologous antihepatic serum].

作者信息

Velev G, Shumkov G

出版信息

Eksp Med Morfol. 1975;14(3):135-9.

PMID:1222706
Abstract

The authors carried out an autoradiographic study on the regeneratory processes in liver of 130 rats, which were treated with carbon tetrachloride and heterologous antiliver serum at various dilutions. The obtained results showed that this serum stimulated the synthesis of DNA in the parenchymal mesenchymal cells of liver, damaged diffusely. The effect of stimulation on DNA-synthesis in the animals of the experimental group, treated with 0,5 ml of heterolougous antiliver serum in dilution of 1:10 with saline, was mostly manifested. According to the authors the stimulation of DNA-synthesis was accomplished most probably by means of the mechanisms of the so called "immune enhancement".

摘要

作者对130只大鼠肝脏的再生过程进行了放射自显影研究,这些大鼠用不同稀释度的四氯化碳和异种抗肝血清进行处理。所得结果表明,这种血清刺激了弥漫性受损肝脏实质间充质细胞中DNA的合成。在用0.5毫升稀释度为1:10的生理盐水稀释的异种抗肝血清处理的实验组动物中,刺激DNA合成的作用最为明显。据作者称,DNA合成的刺激很可能是通过所谓的“免疫增强”机制实现的。

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