Ivamova N
Eksp Med Morfol. 1975;14(3):156-61.
The author examined the pharmacologic spasmolytic action of a pyperasine derivative under the code 4P-79. She examined the effect of the compound on four types of spasms, induced by acethylcholine, nicotine, histamine and serotonine on an isolated rabbit intestine. The mean effective concentrations were determined and they were compared with the mean effective concentrations of papaverine and benzylharmine, estimated in parallel experiments. It was found that 4P-79 had high spasmolytic activity, surpassing several times that of the preparations used for comparison. There was a marked antiserotonine effect on the first place. The compound was examined also on an intestine "in situ" by the method of Nikolaev Comparative experiments with papaverine and deseryl were conducted.
作者研究了代号为4P - 79的哌拉辛衍生物的药理解痉作用。她研究了该化合物对由乙酰胆碱、尼古丁、组胺和血清素在离体兔肠上诱发的四种痉挛类型的影响。测定了平均有效浓度，并将其与在平行实验中估算的罂粟碱和苄基哈尔明的平均有效浓度进行比较。结果发现4P - 79具有很高的解痉活性，超过用于比较的制剂数倍。首先，它对血清素具有显著作用。还采用尼古拉耶夫方法在“原位”肠上对该化合物进行了研究。与罂粟碱和去甲肾上腺素进行了对比实验。
