“干性”：胚胎干细胞和成体干细胞的转录谱分析
"Stemness": transcriptional profiling of embryonic and adult stem cells.
作者信息
Ramalho-Santos Miguel, Yoon Soonsang, Matsuzaki Yumi, Mulligan Richard C, Melton Douglas A
机构信息
Department of Molecular and Cellular Biology and Howard Hughes Medical Institute (HHMI), Harvard University, Cambridge, MA 02138, USA.
出版信息
Science. 2002 Oct 18;298(5593):597-600. doi: 10.1126/science.1072530. Epub 2002 Sep 12.
The transcriptional profiles of mouse embryonic, neural, and hematopoietic stem cells were compared to define a genetic program for stem cells. A total of 216 genes are enriched in all three types of stem cells, and several of these genes are clustered in the genome. When compared to differentiated cell types, stem cells express a significantly higher number of genes (represented by expressed sequence tags) whose functions are unknown. Embryonic and neural stem cells have many similarities at the transcriptional level. These results provide a foundation for a more detailed understanding of stem cell biology.
对小鼠胚胎干细胞、神经干细胞和造血干细胞的转录谱进行比较，以确定干细胞的遗传程序。共有216个基因在所有三种类型的干细胞中富集，其中一些基因在基因组中聚类。与分化细胞类型相比，干细胞表达的功能未知的基因（由表达序列标签表示）数量显著更多。胚胎干细胞和神经干细胞在转录水平上有许多相似之处。这些结果为更详细地了解干细胞生物学奠定了基础。
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