de Manzoni G, Catalano F, Festini M, Lombardo F, Kind R, Rodella L, Ruzzenente A, Zerman G, Valloncini E
Cattedra di Chirurgia d'Urgenza, I Divisione Clinicizzata di Chirurgia Generale, Ospedale Civile Maggiore Borgo Trento, Università degli Studi di Verona.
G Chir. 2002 May;23(5):199-204.
Aim of this study was to evaluate the incidence of esophageal bleeding in a group of 3741 consecutive patients with acute non variceal upper gastrointestinal hemorrhage observed between January 1990 and January 1999 in the First Division of General Surgery--University of Verona. In 627 patients (16.8%) the source of bleeding was exclusively esophageal; and the most frequent causes of esophageal bleeding were reflux esopagitis (408 cases) and Mallory Weiss syndrome (185 cases). At emergency endoscopy, reflux esophagitis was actively bleeding in 83 cases (20.3%) and these patients presented a significantly higher frequency of cirrhosis and severe esophagitis; moreover a higher percentage of patients with bleeding esophagitis have had recent surgery and/or were hospitalized in an intensive care unit. No death directly related to the bleeding were observed, while ten patients deceased from other causes during the hospitalization. In more than half of the 185 patients affected by Mallory-Weiss syndrome a hiatal hernia was described and 69 (37.3%) were alcoholics with associated cirrhosis in 25 cases. In more than 70% of the cases the bleeding from a mucosal tear followed a vomit episode and the lesions were localized at the gastroesophageal junction. Endoscopic sclerotherapy was performed in 89 patients with active bleeding and hemostasis was initially obtained in all patients; rebleeding occurred in 6 patients (6.7%) who needed a further endoscopic treatment. No patients died during hospitalization. Other causes of esophageal bleeding observed were: Candida esophagitis (19 cases), esophageal malignancy (11 cases), benign polyps (2 cases), angiodysplasia (one case) and one case of aorto-esophageal fistula.
本研究的目的是评估1990年1月至1999年1月期间在维罗纳大学普通外科第一科室连续观察的3741例急性非静脉曲张性上消化道出血患者中食管出血的发生率。在627例患者(16.8%)中,出血来源仅为食管;食管出血最常见的原因是反流性食管炎(408例)和马洛里-魏斯综合征(185例)。在急诊内镜检查中,83例(20.3%)反流性食管炎有活动性出血,这些患者肝硬化和严重食管炎的发生率明显更高;此外,食管炎出血患者中近期手术和/或入住重症监护病房的比例更高。未观察到与出血直接相关的死亡病例,而有10例患者在住院期间因其他原因死亡。在185例受马洛里-魏斯综合征影响的患者中,超过一半描述有食管裂孔疝,69例(37.3%)为酗酒者,其中25例伴有肝硬化。在超过70%的病例中,黏膜撕裂出血发生在呕吐发作之后,病变位于胃食管交界处。对89例活动性出血患者进行了内镜硬化治疗,所有患者最初均实现了止血;6例患者(6.7%)再次出血,需要进一步的内镜治疗。住院期间无患者死亡。观察到的食管出血的其他原因包括:念珠菌性食管炎(19例)、食管恶性肿瘤(11例)、良性息肉(2例)、血管发育异常(1例)和主动脉-食管瘘1例。