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Molecular Modeling Indicates that Two Chemically Distinct Classes of Anti-Mitotic Herbicide Bind to the Same Receptor Site(s).分子建模表明，两类化学性质不同的抗有丝分裂除草剂与相同的受体位点结合。
Plant Physiol. 1994 May;105(1):15-18. doi: 10.1104/pp.105.1.15.
2
Cellular and molecular actions of dinitroaniline and phosphorothioamidate herbicides on Plasmodium falciparum: tubulin as a specific antimalarial target.二硝基苯胺和硫代氨基磷酸酯类除草剂对恶性疟原虫的细胞和分子作用：微管蛋白作为特定的抗疟靶点
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Plant tubulins: a melting pot for basic questions and promising applications.植物微管蛋白：基础问题与潜在应用的汇聚之所
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Inhibition of Plant Microtubule Polymerization in vitro by the Phosphoric Amide Herbicide Amiprophos-Methyl.磷酸酰胺类除草剂甲磺草胺体外抑制植物微管聚合。
Science. 1984 May 25;224(4651):874-6. doi: 10.1126/science.224.4651.874.
2
Rapid and Reversible High-Affinity Binding of the Dinitroaniline Herbicide Oryzalin to Tubulin from Zea mays L.二硝基苯胺类除草剂安磺灵与玉米微管蛋白的快速可逆高亲和力结合
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A mutation in the alpha 1-tubulin gene of Chlamydomonas reinhardtii confers resistance to anti-microtubule herbicides.莱茵衣藻α1-微管蛋白基因的突变赋予了对抗微管除草剂的抗性。
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Abnormal leukocyte motility in patients with early-onset periodontitis.早发性牙周炎患者白细胞运动异常。
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Are cytoplasmic microtubules heteropolymers?细胞质微管是异源聚合物吗？
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6
Drugs with colchicine-like effects that specifically disassemble plant but not animal microtubules.具有秋水仙碱样效应的药物，可特异性地分解植物微管而非动物微管。
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7
Beta-tubulin mutants of the unicellular green alga Chlamydomonas reinhardtii.单细胞绿藻莱茵衣藻的β-微管蛋白突变体。
Proc Natl Acad Sci U S A. 1988 Jan;85(1):131-5. doi: 10.1073/pnas.85.1.131.
8
Mechanisms by which mammalian cells acquire resistance to drugs that affect microtubule assembly.
FASEB J. 1989 Mar;3(5):1593-9. doi: 10.1096/fasebj.3.5.2646163.
9
Missense mutations at lysine 350 in beta 2-tubulin confer altered sensitivity to microtubule inhibitors in Chlamydomonas.β2微管蛋白中赖氨酸350处的错义突变导致衣藻对微管抑制剂的敏感性改变。
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10
Binding of the herbicide trifluralin to Chlamydomonas flagellar tubulin.除草剂氟乐灵与衣藻鞭毛微管蛋白的结合。
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分子建模表明，两类化学性质不同的抗有丝分裂除草剂与相同的受体位点结合。

Molecular Modeling Indicates that Two Chemically Distinct Classes of Anti-Mitotic Herbicide Bind to the Same Receptor Site(s).

作者信息

Ellis J. R., Taylor R., Hussey P. J.

机构信息

Zeneca Seeds and Agrochemicals, Jealott's Hill Research Station, Bracknell, Berkshire RG12 6EY, United Kingdom (J.R.E., R.T.).

出版信息

Plant Physiol. 1994 May;105(1):15-18. doi: 10.1104/pp.105.1.15.

DOI:10.1104/pp.105.1.15
PMID:12232182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC159324/
Abstract

Dinitroaniline and phosphorothioamidate herbicides disrupt microtubule assembly from tubulin protein dimers and thereby halt microtubule-based processes such as mitosis in plant cells. Despite the contrasting chemical properties of dinitroaniline and phosphorothioamidate herbicides, a three-dimensional molecular analysis revealed remarkable electrostatic similarity between these two classes of herbicide. From these data it is proposed that dinitroaniline and phosphorothioamidate herbicides share common binding site(s) in the plant cell.

摘要

二硝基苯胺类和硫代磷酰胺类除草剂会破坏微管蛋白二聚体的微管组装，从而使植物细胞中基于微管的过程（如有丝分裂）停止。尽管二硝基苯胺类和硫代磷酰胺类除草剂的化学性质不同，但三维分子分析显示这两类除草剂之间存在显著的静电相似性。基于这些数据，有人提出二硝基苯胺类和硫代磷酰胺类除草剂在植物细胞中共享共同的结合位点。