分子建模表明，两类化学性质不同的抗有丝分裂除草剂与相同的受体位点结合。
Molecular Modeling Indicates that Two Chemically Distinct Classes of Anti-Mitotic Herbicide Bind to the Same Receptor Site(s).
作者信息
Ellis J. R., Taylor R., Hussey P. J.
机构信息
Zeneca Seeds and Agrochemicals, Jealott's Hill Research Station, Bracknell, Berkshire RG12 6EY, United Kingdom (J.R.E., R.T.).
出版信息
Plant Physiol. 1994 May;105(1):15-18. doi: 10.1104/pp.105.1.15.
Abstract
Dinitroaniline and phosphorothioamidate herbicides disrupt microtubule assembly from tubulin protein dimers and thereby halt microtubule-based processes such as mitosis in plant cells. Despite the contrasting chemical properties of dinitroaniline and phosphorothioamidate herbicides, a three-dimensional molecular analysis revealed remarkable electrostatic similarity between these two classes of herbicide. From these data it is proposed that dinitroaniline and phosphorothioamidate herbicides share common binding site(s) in the plant cell.
摘要
二硝基苯胺类和硫代磷酰胺类除草剂会破坏微管蛋白二聚体的微管组装，从而使植物细胞中基于微管的过程（如有丝分裂）停止。尽管二硝基苯胺类和硫代磷酰胺类除草剂的化学性质不同，但三维分子分析显示这两类除草剂之间存在显著的静电相似性。基于这些数据，有人提出二硝基苯胺类和硫代磷酰胺类除草剂在植物细胞中共享共同的结合位点。
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