Uwaifo A, Bassir O
Afr J Med Med Sci. 1979 Mar-Jun;8(1-2):35-9.
Synergism, antagonism and addictive action are three modes of interaction among antibiotics and non-antibiotic compounds. The present paper reports the type of interaction between each of the four main members of the aflatoxin family (BB, G and G) and each of five commonly used classical antibiotics. The test aflatoxins were freshly prepared and confirmed crystalline pure by the use of ultraviolet (u.v.), infrared (i.r.) and nuclear magnetic resonane (n.m.r.) spectroscopy. Interaction between penicillin and aflatoxin B (AFB) gave an antagonistic profile. The interaction of AFB with tetracycline was synergistic. Novobiocin interaction with aflatoxin G also reflected synergism. All other characteristics of interaction between antibiotics and the aflatoxins showed additive profiles.
协同作用、拮抗作用和相加作用是抗生素与非抗生素化合物之间的三种相互作用模式。本文报道了黄曲霉毒素家族的四个主要成员（B1、B2、G1和G2）与五种常用经典抗生素之间的相互作用类型。测试用的黄曲霉毒素是新制备的，并通过紫外（u.v.）、红外（i.r.）和核磁共振（n.m.r.）光谱法确认为结晶纯品。青霉素与黄曲霉毒素B1（AFB1）之间的相互作用呈现拮抗特征。AFB1与四环素的相互作用是协同的。新生霉素与黄曲霉毒素G1的相互作用也表现为协同作用。抗生素与黄曲霉毒素之间相互作用的所有其他特征均呈现相加特征。
