Graham Philip L, Ampofo Krow, Saiman Lisa
Departments of Pediatrics and Epidemiology, Columbia, University, New York, NY 10032, USA.
Pediatr Infect Dis J. 2002 Aug;21(8):798-800. doi: 10.1097/00006454-200208000-00025.
The successful treatment of a 7-month-old infant with shunt-associated ventriculitis caused by vancomycin-resistant Enterococcus faecium is presented. Linezolid was administered intravenously every 8 h; children have a greater volume of distribution and total body clearance than adults and therefore require more frequent dosing. The patient tolerated the therapy without adverse effects.
本文介绍了一名7个月大的婴儿因耐万古霉素屎肠球菌引起分流相关性脑室炎而成功治疗的病例。利奈唑胺每8小时静脉给药一次;儿童的分布容积和全身清除率比成人高,因此需要更频繁给药。该患者耐受该治疗且无不良反应。