Sims Tasha N, Dustin Michael L
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Immunol Rev. 2002 Aug;186:100-17. doi: 10.1034/j.1600-065x.2002.18610.x.
Adhesive interactions play important roles in coordinating T-cell migration and activation, specifically in the formation of the immunological synapse (IS), a specialized cell-cell junction. Recent demonstrations show several molecules implicated in T-cell signaling, including Vav, ADAP, and Rap-1, have major roles in integrin regulation and place adhesion molecules at center stage in addressing the question: what are the signals involved in the formation of the IS and full T-cell activation? This review focuses on the role of integrins as an essential system for both physical adhesion and signaling in T-cell activation. The role of integrins appears to be quite distinct from classical costimulation and has been largely overlooked due to the ubiquitous use of serum in lymphocyte functional assays. Each major signal transduction pathway has branches leading to the nucleus and others that feed back on cytoskeletal and membrane regulation at the IS.
黏附相互作用在协调T细胞迁移和激活过程中发挥着重要作用，特别是在免疫突触（IS）的形成过程中，免疫突触是一种特殊的细胞间连接。最近的研究表明，几种参与T细胞信号传导的分子，包括Vav、ADAP和Rap-1，在整合素调节中起主要作用，并将黏附分子置于解决以下问题的核心位置：IS形成和T细胞完全激活涉及哪些信号？本综述重点关注整合素作为T细胞激活过程中物理黏附和信号传导的重要系统所起的作用。整合素的作用似乎与经典共刺激截然不同，并且由于淋巴细胞功能测定中普遍使用血清，其作用在很大程度上被忽视了。每个主要的信号转导途径都有通向细胞核的分支，以及其他反馈到IS处细胞骨架和膜调节的分支。
