Wagner A, Wieczorek I, Plug M, Kruse H J
Kinderklinik der Bayerischen Julius-Maximilians-Universität, Würzburg.
Vasa. 2002 Aug;31(3):143-51. doi: 10.1024/0301-1526.31.3.143.
The endothelium-derived 21 amino acid peptide endothelin-1 is one of the most potent vasoconstrictors. Endothelin-1 exerts its effects upon a variety of vascular and non-vascular cells through a direct interaction with specific receptors. Beyond its vasoconstrictive action on vascular smooth muscle cells endothelin-1 has mitogenic and pro-inflammatory properties. The present review deals with current experimental and clinical evidence for the involvement of endothelin-1 in several cardiovascular disorders with inflammatory components. We further discuss the potential clinical relevance of the endothelin system and therapeutical perspectives of anti-endothelin strategies in the treatment of cardiovascular disease.
内皮细胞衍生的21个氨基酸的肽内皮素-1是最有效的血管收缩剂之一。内皮素-1通过与特定受体直接相互作用，对多种血管和非血管细胞发挥作用。除了对血管平滑肌细胞的血管收缩作用外，内皮素-1还具有促有丝分裂和促炎特性。本综述探讨了内皮素-1参与几种具有炎症成分的心血管疾病的当前实验和临床证据。我们还讨论了内皮素系统的潜在临床相关性以及抗内皮素策略在心血管疾病治疗中的治疗前景。
