Weigl J A I, Puppe W, Schmitt H J
University Children's Hospital, Kiel, Germany.
Infection. 2002 Aug;30(4):186-92. doi: 10.1007/s15010-002-2159-1.
Elaborate, long-term data on the rhythm, seasonality and severity of the yearly respiratory syncytial virus (RSV) epidemics in Germany are lacking.
A longitudinal investigation was undertaken of children from birth to 16 years of age admitted with an RSV infection in the two pediatric hospitals in Kiel between July 1994 and June 2001. To compare the severity of the individual seasons, the incidences and the proportion of RSV-positive hospitalized children aged 0 to 2 years from the denominator area of Kiel were compared.
During the 7-year period, the nasopharyngeal aspirates of 2,367 children were investigated; RSV was detected in 384 (16.2%). The seasons from 1994/95 to 1996/97 started late (December to January) and ended between March and May. Since 1997/98 it seems that a late season is followed by an early season (start in September to October) in a 2-year pattern.
No fixed rhythm of the RSV season can be identified as yet. Ascertainment bias is unlikely to explain the differences in rhythm. The incidence of RSV-positive hospitalizations seems to be increasing.
德国缺乏关于每年呼吸道合胞病毒（RSV）流行的节律、季节性和严重程度的详细长期数据。
对1994年7月至2001年6月期间在基尔两家儿科医院因RSV感染入院的出生至16岁儿童进行了纵向调查。为比较各季节的严重程度，对基尔分母区域0至2岁RSV阳性住院儿童的发病率和比例进行了比较。
在7年期间，对2367名儿童的鼻咽抽吸物进行了调查；384例（16.2%）检测到RSV。1994/95至1996/97年的季节开始较晚（12月至1月），结束于3月至5月之间。自1997/98年以来，似乎以两年为一个模式，晚季之后跟着早季（9月至10月开始）。
目前尚未确定RSV季节的固定节律。确定偏倚不太可能解释节律上的差异。RSV阳性住院的发病率似乎在上升。
