Guvenc T, Haligur M, Orman M N, Haziroglu R
Pathology Department, Veterinary Medicine Faculty, Ankara University, 06110 Diskapi, Ankara, Turkey.
Acta Vet Hung. 2002;50(3):315-21. doi: 10.1556/AVet.50.2002.3.8.
Cell proliferation and apoptosis in canine cutaneous histiocytomas and transmissible venereal tumours were examined in twenty cases. The Ki-67 immunohistochemistry and Tunel methods were used to detect mitotic activity and apoptosis, respectively. The number of Ki-67 immunoreactive cells was 11.65 (+/- 1.1706) in canine cutaneous histiocytomas and 17 (+/- 2.1751) in transmissible venereal tumours. The mean values of apoptotic cells for canine cutaneous histiocytomas and transmissible venereal tumours were 13.25 (+/- 1.8758) and 8.52 (+/- 1.1007), respectively. It was considered that mitotic activity and apoptotic indices were useful in differentiation of canine cutaneous histiocytomas and transmissible venereal tumours. The correlation values for canine cutaneous histiocytomas and transmissible venereal tumours were 0.359 (+/- 0.330) and -0.232 (+/- 0.344), respectively. No significant (P > 0.05) correlation was found between mitosis and apoptosis in these two tumour types.
对20例犬皮肤组织细胞瘤和传染性性病肿瘤的细胞增殖和凋亡情况进行了检查。分别采用Ki-67免疫组织化学法和Tunel法检测有丝分裂活性和凋亡情况。犬皮肤组织细胞瘤中Ki-67免疫反应性细胞数量为11.65（±1.1706），传染性性病肿瘤中为17（±2.1751）。犬皮肤组织细胞瘤和传染性性病肿瘤凋亡细胞的平均值分别为13.25（±1.8758）和8.52（±1.1007）。认为有丝分裂活性和凋亡指数有助于犬皮肤组织细胞瘤和传染性性病肿瘤的鉴别。犬皮肤组织细胞瘤和传染性性病肿瘤的相关值分别为0.359（±0.330）和-0.232（±0.344）。在这两种肿瘤类型中，有丝分裂和凋亡之间未发现显著相关性（P>0.05）。
