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[消化性软斑病]

[Digestive malacoplakia].

作者信息

Ennibi K, Mikdame M, Bahrouch L, Châari J, Toloune F, Archane M I

机构信息

Service de médecine interne A. Hôpital militaire d'instruction Mohammed V, Rabat, Maroc.

出版信息

Presse Med. 2002 Aug 24;31(27):1263-5.

Abstract

INTRODUCTION

Malacoplakia, a chronic granulomatous disease, rarely involves the digestive tube and, when it does, takes on a pseudotumoral aspect.

OBSERVATION

A 37 year-old man was hospitalized for chronic diarrhea that had progressed over 15 years. He exhibited an edematous-ascitic syndrome and bilateral pleurisy together with, biologically, a malabsorption syndrome. The endoscopic examinations (fibroscopy and colonoscopy) revealed polypoid tumor-like formations. An image of tumoral stenosis of the sigmoid-colic junction was revealed on barite lavage. Histological examination of the surgical sample (wide left colectomy of one third of the transverse) was suggestive of malacoplakia (histiocytes with characteristic Michaelis-Gutmann bodies).

DISCUSSION

Malacoplakia is an inflammatory disease predominantly affecting the urogenital tract. Other organs can be involved. Its clinical symptomatology is highly disparate. The interest of this disease is in its pathogenesis, on which, in fact, its treatment is based.

摘要

引言

软斑病是一种慢性肉芽肿性疾病,很少累及消化道,一旦累及则呈现假瘤样外观。

病例报告

一名37岁男性因持续15年的慢性腹泻入院。他表现出水肿 - 腹水综合征和双侧胸膜炎,生物学检查显示存在吸收不良综合征。内镜检查(纤维镜检查和结肠镜检查)发现息肉样肿瘤样病变。钡剂灌肠显示乙状结肠 - 结肠交界处肿瘤性狭窄影像。手术标本(左半结肠及三分之一横结肠广泛切除术)的组织学检查提示为软斑病(具有特征性迈克尔is - 古特曼小体的组织细胞)。

讨论

软斑病是一种主要累及泌尿生殖道的炎症性疾病。其他器官也可能受累。其临床症状差异很大。该疾病的关注点在于其发病机制,事实上,其治疗正是基于此。

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