Cavagnini F, Peracchi M, Panerai A E, Pinto M
Quad Sclavo Diagn. 1975 Jun;11(2):372-81.
Twenty hyperthyroid patients were investigated for growth hormone (GH) and immunoreactive insulin (IRI) secretion in response to insulin hypoglycaemia, arginine infusion and glucose-induced hyperglycaemia. GH response to either insulin hypoglycaemia or arginine infusion was significantly reduced in these patients compared with 20 normal subjects. Thyrotoxic patients also displayed an abnormal GH pattern after a 100 g oral glucose load: in fact, serum GH underwent a paradoxical increase in spite of abnormally high levels attained by blood glucose. IRI secretion was also clearly reduced in response to arginine infusion and moderately blunted after oral glucose. In a group of patients re-evaluated under euthyroid conditions, a fair increase of GH response to the provocative stimuli jointly with the restoration of a normal suppressibility of serum GH by glucose were noted; by contrast, no significant change of IRI response to arginine or glucose took place. Likewise, the impairment of glucose tolerance was not improved. These findings indicate that an impairment of GH and IRI secretion is present in hyperthyroidism. The possibility that a potentiation of the catecholamine effects caused by the thyroid hormones is involved in this alteration deserves consideration.
对20例甲状腺功能亢进患者进行了研究，以观察其在胰岛素低血糖、精氨酸输注和葡萄糖诱导的高血糖情况下生长激素（GH）和免疫反应性胰岛素（IRI）的分泌情况。与20名正常受试者相比，这些患者对胰岛素低血糖或精氨酸输注的GH反应显著降低。甲状腺毒症患者在口服100g葡萄糖负荷后也表现出异常的GH模式：事实上，尽管血糖达到异常高水平，但血清GH却出现了反常升高。对精氨酸输注的IRI分泌也明显减少，口服葡萄糖后则中度减弱。在一组甲状腺功能正常状态下重新评估的患者中，观察到对刺激的GH反应有适度增加，同时葡萄糖对血清GH的正常抑制作用得以恢复；相比之下，IRI对精氨酸或葡萄糖的反应没有显著变化。同样，葡萄糖耐量受损也没有改善。这些发现表明甲状腺功能亢进时存在GH和IRI分泌受损。甲状腺激素引起的儿茶酚胺效应增强参与这种改变的可能性值得考虑。
