Hiroi Hisahiko, Osuga Yutaka, Tarumoto Yoshiko, Shimokama Tatsuro, Yano Tetsu, Yokota Harushige, Taketani Yuji
Department of Obstetrics and Gynecology, Hitachi General Hospital, Ibaraki, Japan.
Oncology. 2002;63(2):201-4. doi: 10.1159/000063810.
Although Brenner tumors with endocrine activities have been reported, the source or mechanisms for hormone production is poorly known at present.
A 66-year-old Japanese woman presented with atypical vaginal bleeding. A left ovarian tumor was detected on ultrasonography and CT scanning. Her serum estradiol level was elevated (73.5 pg/ml). We performed total hysterectomy, bilateral salpingo-oophorectomy and partial omentectomy. The ovarian tumor was diagnosed as a benign Brenner tumor associated with simple hyperplasia of the endometrium. Postoperatively, the serum estradiol level decreased. Immunoreactivity of cytochrome P-450 aromatase was detected in stromal cells.
Stromal contribution to the secretion of estrogen was shown in this case. Considering the known source of estrogen production being tumor cells in certain cases of Brenner tumor, there seem to be two types of estrogen-producing Brenner tumors depending on the source of estrogen, i.e. tumor cells or stromal cells.
虽然已有关于具有内分泌活性的勃勒纳瘤的报道，但目前激素产生的来源或机制尚不清楚。
一名66岁的日本女性出现非典型阴道出血。超声检查和CT扫描发现左侧卵巢肿瘤。她的血清雌二醇水平升高（73.5 pg/ml）。我们进行了全子宫切除术、双侧输卵管卵巢切除术和部分大网膜切除术。卵巢肿瘤被诊断为与子宫内膜单纯性增生相关的良性勃勒纳瘤。术后，血清雌二醇水平下降。在间质细胞中检测到细胞色素P-450芳香化酶的免疫反应性。
该病例显示了间质对雌激素分泌的作用。考虑到在某些勃勒纳瘤病例中已知雌激素产生的来源是肿瘤细胞，根据雌激素的来源，即肿瘤细胞或间质细胞，似乎存在两种产生雌激素的勃勒纳瘤。
