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[各种肝脏疾病中乙肝表面抗原的发生率(放射免疫法与被动血凝法的比较)]

[Incidence of HBAg in various liver diseases (comparison between radioimmunologic methods and methods of passive hemagglutination)].

作者信息

Claar G M, Alvaro M C, Ascione A, De Bellis G, Sodano S, Varone G L

出版信息

Quad Sclavo Diagn. 1975 Jun;11(2):561-6.

PMID:1223959
Abstract

In order to determine the frequency of HBAg in Campania, the AA. have examined a large number of liver patients accurately selected and subdivided in five classes: acute hepatitis, chronic hepatitis, cirrhosis, hepatocarcinoma, and various liver diseases. They have employed radioimmuno assays (RIA) with human and guinea pig antibodies and techniques of passive haemoagglutination. The percentage of HBAg positive subjects among the various classes of liver diseases determined with these techniques is significantly higher than the one remarked by the AA. in 1972 by electrosineresis on the same population. Both RIA and haemoagglutination supply satisfactory results, although for haemoagglutination one must remember the subjectiveness of the reading.

摘要

为确定坎帕尼亚地区乙肝表面抗原(HBAg)的出现频率,研究人员精确挑选了大量肝病患者,并将其分为五类:急性肝炎、慢性肝炎、肝硬化、肝癌以及其他各类肝病。他们采用了针对人类和豚鼠抗体的放射免疫分析法(RIA)以及被动血凝技术。运用这些技术测定的各类肝病中HBAg阳性受试者的百分比,显著高于研究人员在1972年对同一人群进行电凝法检测时所记录的百分比。放射免疫分析法和血凝法均得出了令人满意的结果,不过对于血凝法,必须注意读数的主观性。

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