Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction.
作者信息
Saldanha S A, Birch L M, Webb M E, Nabbs B K, von Delft F, Smith A G, Abell C
机构信息
University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW.
出版信息
Chem Commun (Camb). 2001 Sep 21(18):1760-1. doi: 10.1039/b106090m.
DOI:10.1039/b106090m
PMID:12240302
Abstract
The decarboxylation of L-aspartate by E. coli L-aspartate-alpha-decarboxylase (ADC) is shown to occur with retention of configuration; analysis of the protein structure identifies Tyr58 as the proton donor in the decarboxylation mechanism.
摘要
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