Nitiyanant W, Tandhanand S, Mahtab H, Zhu X X, Pan C Y, Raheja B S, Sathe S R, Soegondo S, Soewondo P, Kim Y S, Embong M, Lantion-Ang L, Lim-Abraham M A, Lee W W R, Wijesuriya M, Tai T Y, Chuang L M, Le H L, Cockram C, Jorgensen L N, Yeo J P
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok, Thailand.
Curr Med Res Opin. 2002;18(5):317-27. doi: 10.1185/030079902125000822.
The aim of this study was to describe the glycaemic and metabolic control and diabetes-related complications in type 1 and type 2 Asian patients.
Data of diabetes patients from 230 diabetes centres in 12 Asian regions were collected on a retrospective-prospective basis through review of medical records, interview and laboratory assessments. Analysis of glycated haemoglobin (HbA1c) was carried out in central laboratories appointed by Bio-Rad. The data collection case record forms were scanned electronically.
22177 patients with valid data made up the analysis population. Among patents with type 1 and type 2 diabetes, there was a higher proportion of women than men (53% vs. 47% for type 1 patients and 56% vs. 44% for type 2 diabetes). Hypertension (61%) and overweight (40% with BMI > or = 25 kg/m2 were common in type 2 patients. Dyslipidaemia was also present in at least half of both types of patients. Control of glycaemia (mean HbA,1c and fasting blood glucose [FBG]) was poor in type 1 (9.9 +/- 2.5%; 10.2 +/- 5.2 mmol/l) and type 2 patients (8.5 +/- 2.0%; 8.9 +/- 3.4 mmol/l). Glycaemia in the majority of both types of patients fell short of those stipulated by various guidelines. In type 2 patients, glycaemia deteriorated (HbA1c > 7.5%, FBG > or = 7.0 mmol/l) with duration of diabetes > 7 years. Both types of diabetes appear to share a similar high prevalence of complications of cataract, retinopathy and neuropathy, although the prevalence of cataract (27%) and neuropathy (35%) was higher in type 2 diabetes. Screening for microalbuminuria was not common.
The Inadequate metabolic and hypertension control, especially in type 2 patients, needs to be addressed.
本研究旨在描述1型和2型亚洲糖尿病患者的血糖和代谢控制情况以及糖尿病相关并发症。
通过病历回顾、访谈和实验室评估，以回顾性-前瞻性方式收集了来自亚洲12个地区230个糖尿病中心的糖尿病患者数据。糖化血红蛋白（HbA1c）分析在伯乐公司指定的中心实验室进行。数据收集病例记录表进行了电子扫描。
22177例有有效数据的患者构成了分析人群。在1型和2型糖尿病患者中，女性比例高于男性（1型患者中女性占53%，男性占47%；2型糖尿病患者中女性占56%，男性占44%）。高血压（61%）和超重（BMI≥25 kg/m2者占40%）在2型患者中较为常见。两种类型的患者中至少一半存在血脂异常。1型患者（9.9±2.5%；10.2±5.2 mmol/l）和2型患者（8.5±2.0%；8.9±3.4 mmol/l）的血糖控制（平均HbA1c和空腹血糖[FBG]）较差。大多数两种类型患者的血糖均未达到各种指南规定的水平。在2型患者中，糖尿病病程>7年时血糖恶化（HbA1c>7.5%，FBG≥7.0 mmol/l）。两种类型的糖尿病在白内障、视网膜病变和神经病变并发症方面似乎都有相似的高患病率，尽管2型糖尿病中白内障（27%）和神经病变（35%）的患病率更高。微量白蛋白尿筛查并不常见。
需要解决代谢和高血压控制不足的问题，尤其是在2型患者中。
