Sambrook Jennifer G, Russell Roslin, Umrania Yagnesh, Edwards Yvonne J K, Campbell R Duncan, Elgar Greg, Clark Melody S
Fugu Genomics, HGMP Resource Centre, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SB, UK.
Immunogenetics. 2002 Sep;54(6):367-80. doi: 10.1007/s00251-002-0478-0. Epub 2002 Jul 16.
The major histocompatibility complex (MHC) region in fish has been subjected to piecemeal analysis centering on the in-depth characterization of single genes. The emphasis has been on those genes proven to be involved in the immune response such as the class I and class II antigen presenting genes and the complement genes. The Fugu genome data presents the opportunity to examine the short-range linkage of potentially all the human MHC orthologues and examine conserved synteny with the human and, to a more limited extent, zebrafish genomes. Analysis confirms the existence of a limited MHC locus in Fugu comprising the MHC class Ia genes and associated class II region genes involved in class I antigen presentation. Identification of additional human MHC orthologues indicates the completely dispersed nature of this region in fish, with a maximum of six MHC genes maintained within close proximity in any one contig. The majority of the other genes are present in the genome data as either singletons or pairs. Comparison with zebrafish substantiates previously observed linkages between class III region orthologues and hints at an ancient conserved class III region.
鱼类的主要组织相容性复合体（MHC）区域一直是以单个基因的深入特征为中心进行零碎分析的。重点一直放在那些已被证明参与免疫反应的基因上，如I类和II类抗原呈递基因以及补体基因。河豚基因组数据提供了一个机会，可以研究潜在的所有人类MHC直系同源基因的短程连锁，并研究与人类以及在更有限程度上与斑马鱼基因组的保守同线性。分析证实河豚中存在一个有限的MHC基因座，其包含参与I类抗原呈递的MHC Ia类基因和相关的II类区域基因。额外人类MHC直系同源基因的鉴定表明该区域在鱼类中具有完全分散的性质，在任何一个重叠群中最多有六个MHC基因紧密相邻。大多数其他基因在基因组数据中以单拷贝或成对形式存在。与斑马鱼的比较证实了先前观察到的III类区域直系同源基因之间的连锁，并暗示存在一个古老的保守III类区域。
