Roberts D C, Corcoran M E, Fibiger H C
Pharmacol Biochem Behav. 1977 Jun;6(6):615-20. doi: 10.1016/0091-3057(77)90084-3.
The role of ascending noradrenergic (NA) and dopaminergic (DA) systems in intravenous self-administration of cocaine in rats was investigated by examining the effects of 6-hydroxydopamine-induced lesions of these systems on responding for the drug on a FR-1 schedule of reinforcement. Lesions of the dorsal and ventral NA bundles that reduced hippocampal-cortical NA by 96% and hypothalamic NA by 72% failed to have any effects on responding for cocaine. Lesions of the nucleus accumbens that reduced the DA content of this nucleus by 90% resulted in a significant and long-lasting (15 days) reduction in self-administration of cocaine. Apomorphine self-administration was not affected in the same animals. Identical lesions of the n accumbens had only transient (2-3 days) effects on food-reinforced operant responding, suggesting that the prolonged disruption of cocaine self-administration was not the result of motor deficits. The results are discussed with reference to the possibility that DA terminals in the n accumbens may mediate some of the positive reinforcing properties of cocaine.
通过检测6-羟基多巴胺诱导的去甲肾上腺素能（NA）和多巴胺能（DA）系统损伤对大鼠在固定比率1强化程序下对可卡因反应的影响，研究了上行NA和DA系统在大鼠静脉注射可卡因自我给药中的作用。背侧和腹侧NA束损伤使海马-皮质NA减少96%，下丘脑NA减少72%，但对可卡因反应没有任何影响。伏隔核损伤使该核的DA含量减少90%，导致可卡因自我给药显著且持久（15天）减少。在同一动物中，阿扑吗啡自我给药不受影响。伏隔核相同损伤对食物强化的操作性反应只有短暂（2-3天）影响，表明可卡因自我给药的长期中断不是运动缺陷的结果。结合伏隔核中DA终末可能介导可卡因一些正性强化特性的可能性对结果进行了讨论。
