HIV-1病毒库

HIV-1 reservoirs.

作者信息

Pomerantz Roger J

机构信息

Dorrance H. Hamilton Laboratory, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

出版信息

Clin Lab Med. 2002 Sep;22(3):651-80, vi. doi: 10.1016/s0272-2712(02)00005-7.

DOI:10.1016/s0272-2712(02)00005-7

PMID:12244591

Abstract

In most infected individuals, HIV-1 replicates high levels throughout the duration of infection, including the clinically quiescent phase of disease. The level of this active viral replication correlates directly with disease progression and survival. The advent of combination therapeutics for HIV-1 (i.e., highly active antiretroviral therapy [HAART]) has led to dramatic reductions in viral replication in vivo and morbidity and mortality, at least in the developed world.

摘要

在大多数受感染个体中，HIV-1在整个感染期间都会大量复制，包括疾病的临床静止期。这种活跃的病毒复制水平与疾病进展和生存率直接相关。针对HIV-1的联合疗法（即高效抗逆转录病毒疗法[HAART]）的出现，至少在发达国家，已导致体内病毒复制、发病率和死亡率大幅降低。