Arendt R
Z Gesamte Inn Med. 1975 Dec 1;30(23):749-52.
A survey of pathogenesis, pathobiochemistry, pathological anatomy, clinic, diagnostics and therapy of the Zollinger-Ellison-syndrome is given. The Zollinger-Ellison-syndrome is, it is true, relatively rare, but its limitation from the usual peptic ulcer has great practical consequences. The suspicion of a Zollinger-Ellison-syndrome is aroused by therapy-resistent ulcers, which in every third person are associated with a diarrhoea, by recidivations of ulcer after gastric operations and by a large basal secretion of acid. The decisive diagnostic means is the serum gastrin determination. The only promising therapy is, as a rule, the gastrectomy.
本文对佐林格-埃利森综合征的发病机制、病理生物化学、病理解剖学、临床、诊断及治疗进行了综述。诚然，佐林格-埃利森综合征相对罕见，但将其与常见消化性溃疡区分开来具有重大实际意义。对佐林格-埃利森综合征的怀疑可由难治性溃疡引发（每三分之一的患者伴有腹泻）、胃手术后溃疡复发以及大量基础胃酸分泌引起。决定性的诊断方法是测定血清胃泌素。通常，唯一有前景的治疗方法是胃切除术。
