[Diagnosis of the early stages of diabetes and prevention of diabetes manifestations].

According to our experiences the value of the GIT in the diagnostics of the pre-stages of diabetes on account of the recognizability of the two phases of secretion of insulin and the good reproducibility is above the value of the oGTT and iGTT. In consequence of the large methodical expenditure it is left to the highly specialized stationary diagnostics. The development of the carbohydrate intolerance is concomitant with a significant reduction of the glucose-induced insulin secretion in the early phase. In contrast to this, in about 70 per cent the second phase of secretion corresponds to the normal when the pathological carbohydrate tolerance appears and is significantly reduced to 60 per cent only at the time of the manifestation of diabetes. The reduction of weight as well as buformin are suitable therapeutics of the manifestation prophylaxis. In these cases in the adipose asymptomatic diabetes should primarily always be striven for a normalisation of the body-weight, whereas for test persons with normal weight the indication for the buformin-therapy is given.