支原体诱导性关节炎大鼠血清和脾脏中的脱氧核糖核酸酶活性
Desoxyribonuclease activity in the serum and spleen of rats with mycoplasma induced arthritis.
作者信息
Vincze S, Klein G, Altmann H
出版信息
Z Rheumatol. 1975 Jan-Feb;34(1-2):49-54.
The endodesoxyribonuclease and exodesoxyribonuclease activities were measured in the spleen cytoplasma fraction and serum of rats with mycoplasma induced arthritis and adjuvant arthritis. A higher exonuclease activity was found in the spleen cytoplasma of adjuvant arthritis rats. During the regression of mycoplasma arthritis an increased activity of exonuclease was detected in the serum, but in the acute stage of inflammation the exonuclease activity was similar to the control values. A higher endonuclease activity was found in the spleen cytoplasma fraction of rats with mycoplasma arthritis. The possible origin of the endonuclease and its role in arthritis are discussed.
在支原体诱导性关节炎和佐剂性关节炎大鼠的脾脏细胞质组分和血清中检测了核酸内切脱氧核糖核酸酶和核酸外切脱氧核糖核酸酶活性。在佐剂性关节炎大鼠的脾脏细胞质中发现了较高的核酸外切酶活性。在支原体关节炎消退期间，血清中核酸外切酶活性增加，但在炎症急性期，核酸外切酶活性与对照值相似。在支原体关节炎大鼠的脾脏细胞质组分中发现了较高的核酸内切酶活性。本文讨论了核酸内切酶的可能来源及其在关节炎中的作用。
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