动物和人类中的维生素E缺乏与癫痫发作

Vitamin E deficiency and seizures in animals and man.

作者信息

Ogunmekan A O

出版信息

Can J Neurol Sci. 1979 Feb;6(1):43-5. doi: 10.1017/s0317167100119353.

DOI:10.1017/s0317167100119353

Abstract

Study of 100 children with grand mal convulsive disorders and 100 medically healthy children of matching age showed significantly lower plasma levels of vitamin E in the former (means 632.2 +/- 17.3 and 822.5 +/- 21.8 micrograms/dl respectively; p less than 0.001). This finding accords with the ability to prevent seizures in rodents by giving alpha-tocopherol before exposing them to a convulsion-inducing environment.

摘要

对100名患有癫痫大发作紊乱症的儿童和100名年龄匹配的健康儿童进行研究，结果显示前者的血浆维生素E水平显著较低（分别为632.2±17.3和822.5±21.8微克/分升；p<0.001）。这一发现与在啮齿动物暴露于诱发惊厥的环境之前给予α-生育酚可预防惊厥的能力相符。