青蛙肝脏糖原合酶。I型和D型之间的体外及体内相互转化
Frog liver glycogen synthase. In vitro and in vivo interconversions between I and D forms.
作者信息
Castiñeiras M J, Boronat A, Itarte E, Guinovart J J, Pérez M R
机构信息
Department of Biochemistry, University of Barcelona, School of Pharmacy, Spain.
出版信息
Comp Biochem Physiol B. 1978;59(4):277-84. doi: 10.1016/0305-0491(78)90002-0.
PMID:122565
Abstract
- Frog liver has enzymatic systems able to interconvert glycogen synthase. 2. D to I conversion is achieved in vitro by incubation at 30 degrees C. ATP, ADP, inorganic phosphate and glycogen are inhibitors of this conversion, whereas glucose-6-P and Mg2+ stimulate it. 3. I to D conversion in vitro depends on ATP-Mg2+. Cyclic-AMP activates this conversion, while glucose-6-P inhibits it. 4. Injection of glucose, ribose, mannose, fructose, galactose, and cortisone into frogs increase liver percentage of I activity. 5. Glucagon and adrenaline decrease percentage of I activity.
摘要
- 蛙肝具有能使糖原合酶相互转化的酶系统。2. 在30℃孵育可在体外实现从D型到I型的转化。ATP、ADP、无机磷酸盐和糖原是这种转化的抑制剂，而6-磷酸葡萄糖和Mg2+则刺激这种转化。3. 体外从I型到D型的转化依赖于ATP-Mg2+。环磷酸腺苷激活这种转化，而6-磷酸葡萄糖抑制它。4. 向蛙体内注射葡萄糖、核糖、甘露糖、果糖、半乳糖和可的松会增加肝脏中I型活性的百分比。5. 胰高血糖素和肾上腺素降低I型活性的百分比。
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