脊椎动物肝脏中的糖异生作用。
Gluconeogenesis in vertebrate livers.
作者信息
Phillips J W, Hird F J
机构信息
Russel Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria, Australia.
出版信息
Comp Biochem Physiol B. 1977;57(2):127-31. doi: 10.1016/0305-0491(77)90161-4.
PMID:122579
Abstract
- The hypothesis is advanced that it would be logical for a tissue (liver) to evolve as a gluconeogenic organ in order to recover the lactate produced as a result of rapid and sustained contraction of skeletal muscle. 2. Lactate was present in skeletal muscle of all animals examined and increased following electrical stimulation. It was also present in the blood. 3. Gluconeogenesis from lactate occurred in liver slices of all animals excepting amphibia. However, livers of these animals also contained much glycogen and are probably gluconeogenic. 4. Phosphoenolpyruvate carboxykinase was present in all animals investigated; pyruvate carboxylase was present in all animals excepting the toad.
摘要
- 提出的假设是，为了回收骨骼肌快速持续收缩产生的乳酸，组织（肝脏）进化为糖异生器官是符合逻辑的。2. 在所有检查的动物的骨骼肌中都存在乳酸，电刺激后乳酸增加。它也存在于血液中。3. 除两栖动物外，所有动物的肝切片中都发生了从乳酸生成葡萄糖的过程。然而，这些动物的肝脏也含有大量糖原，可能具有糖异生作用。4. 在所有研究的动物中都存在磷酸烯醇式丙酮酸羧激酶；除蟾蜍外，所有动物都存在丙酮酸羧化酶。
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