促黄体生成激素释放激素（LHRH）抗血清给药对恒河猴促性腺激素分泌的影响。
The effect of luteinizing hormone releasing hormone (LHRH) antiserum administration on gonadotropin secretion in the rhesus monkey.
作者信息
McCormack J T, Plant T M, Hess D L, Knobil E
机构信息
Department of Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261.
出版信息
Endocrinology. 1977 Mar;100(3):663-7. doi: 10.1210/endo-100-3-663.
Single iv injections of a rabbit antiserum to synthetic LHRH promptly suppressed serum LH and FSH concentrations in ovariectomized rhesus monkeys. Gonadotropin levels remained depressed for 10-21 days, the approximate duration of enhanced LHRH binding activity in the circulation. Doses of LHRH antiserum sufficient to reduce tonic gonadotropin secretion did not modify the time course or magnitude of estrogen-induced gonadotropin surges. These negative findings, however, cannot be interpreted to signify that such surges are not caused by a release of LHRH.
给去卵巢的恒河猴单次静脉注射兔抗合成促黄体生成素释放激素（LHRH）抗血清，可迅速抑制血清中促黄体生成素（LH）和促卵泡生成素（FSH）的浓度。促性腺激素水平在10 - 21天内持续降低，这与循环中LHRH结合活性增强的大致持续时间相符。足以降低促性腺激素基础分泌量的LHRH抗血清剂量，并未改变雌激素诱导的促性腺激素激增的时间进程或幅度。然而，这些阴性结果不能被解释为表明这种激增不是由LHRH释放引起的。
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