Norpoth K, Raidt H, Witting U, Müller G, Norpoth R
Klin Wochenschr. 1975 Nov 15;53(22):1075-6. doi: 10.1007/BF01614384.
Ifosfamide as well as its stable alkylating metabolites namely carboxy-Ifosfamide and two dechloroethylated compounds were determined in the urine of a patient with progredient lung carcinoma who had been treated with 6 g of the drug. Quantitative measurements were carried out using a colorimetric procedure which consists of TL-spectrophotometric determinations on sheets which had previously been sprayed with 4-pyridinaldehyde-2-benzothiazolylhydrazone. In the case investigated the Ifosfamide was found to have been converted largely into two dechloroethylated compounds (48%) and only a small portion of carboxy-Ifosfamide (2.2%).
在一名接受了6克异环磷酰胺治疗的进展期肺癌患者的尿液中，检测到了异环磷酰胺及其稳定的烷基化代谢产物，即羧基异环磷酰胺和两种脱氯乙基化化合物。采用比色法进行定量测定，该方法包括对预先用4-吡啶甲醛-2-苯并噻唑腙喷洒过的薄层进行薄层分光光度测定。在所研究的病例中，发现异环磷酰胺大部分已转化为两种脱氯乙基化化合物（48%），只有一小部分羧基异环磷酰胺（2.2%）。
