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[用异种胎儿细胞和恶性肿瘤免疫后人体中胎儿抗原引起的淋巴细胞致敏(作者译)]

[Lymphocyte sensibilisation by fetal antigens in man after immunisation with xenogeneic fetal cells and with malignant tumors (author's transl)].

作者信息

Renner H, Renner K

出版信息

Klin Wochenschr. 1975 Nov 15;53(22):1077-9. doi: 10.1007/BF01614385.

Abstract

Specific lymphocyte sensibilisation in man can be shown one to four months after injection of xenogeneic fetal cells by means of in vitro lymphocyte stimulation by the previous injected lyophilised fetal antigens. Adult lyophilised xenogeneic cells demonstrate no stimulatory effect. In the same test positive lymphocyte stimulation against lyophilised fetal cells can be demonstrated in about 50% of a group of patients with malignant tumors. These preliminary findings could be a possible link in evaluating the effects of fetal cells as a form of tumor-immunotherapy in man.

摘要

通过先前注射的冻干胎儿抗原进行体外淋巴细胞刺激,可在注射异种胎儿细胞一至四个月后显示出人体中特定的淋巴细胞致敏。成人冻干异种细胞未显示出刺激作用。在同一试验中,在一组恶性肿瘤患者中,约50%可证明对冻干胎儿细胞有阳性淋巴细胞刺激。这些初步发现可能是评估胎儿细胞作为一种人体肿瘤免疫治疗形式的效果的一个可能环节。

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