A wide spectrum of fetal antigens is found not only in fetal cells but also in tumor cells. These substances are termed onco-fetal antigens. One group out of these antigens has developed special diagnostic interest and importance, first of all the carcino-embryonic antigen (CEA) in adenocarcinomas of the gastrointestinal tract. Another class of fetal antigens consists of tumor-assoicated membrane-antigens against these the organism may develop a cytotoxic reaction and in the long run, may repulse the tumor like an incompatible graft. The verification of this second group was possible by means of various cross reactions. These latter fetal antigens eventually may be utilized for purposes of immunological prophylaxis and therapy.
多种胎儿抗原不仅存在于胎儿细胞中,也存在于肿瘤细胞中。这些物质被称为癌胚抗原。其中一类抗原已引起特别的诊断关注并具有重要意义,首先是胃肠道腺癌中的癌胚抗原(CEA)。另一类胎儿抗原由肿瘤相关膜抗原组成,机体可能针对这些抗原产生细胞毒性反应,从长远来看,可能像排斥不相容移植物一样排斥肿瘤。通过各种交叉反应可以证实第二类抗原的存在。这些后期的胎儿抗原最终可用于免疫预防和治疗目的。