Chaudry M A, James K C, Ng C T, Nicholls P J
J Pharm Pharmacol. 1976 Dec;28(12):882-5. doi: 10.1111/j.2042-7158.1976.tb04085.x.
The anabolic and androgenic activities of the formate to undecanoate esters of nandrolone and formate to valerate esters of androstanolone, after intramuscular injection, have been determined in rat. The response to a given dose was measured as cumulative weight (the area under the plot of weight of indicator organ against time). Levator anus muscle was used to assess anabolic activity, and the sum of the cumulative weight for prostate and seminal vesicles for androgenic activity. Log dose-log cumulative weights plots were parallel, and biological activities were expressed as the cumulative weight corresponding to a 2 muM dose, calculated from the regression lines. Anabolic-androgenic ratios for both series were calculated and were found to be minimum in the region of the propionate and butyrate. The anabolic-androgenic ratios of the nandrolone esters continued to increase after the minimum, as the series ascended. This method is believed to give a reliable assessment of anabolic and androgenic activities of steroid esters.
已在大鼠体内测定了诺龙的甲酸酯至十一酸酯以及雄烷醇酮的甲酸酯至戊酸酯经肌肉注射后的同化和雄激素活性。对给定剂量的反应以累积重量（指示器官重量与时间关系图下的面积）来衡量。提肛肌用于评估同化活性，前列腺和精囊的累积重量总和用于评估雄激素活性。对数剂量-对数累积重量图是平行的，生物活性以对应于2μM剂量的累积重量表示，该累积重量由回归线计算得出。计算了两个系列的同化-雄激素比率，发现丙酸酯和丁酸酯区域的比率最低。随着系列上升，诺龙酯的同化-雄激素比率在达到最低值后继续增加。据信该方法能可靠地评估类固醇酯的同化和雄激素活性。
