Mceuen C S
Am J Cancer. 1939 Aug;36(4):551-66.
The occurrence of 3 tar cancers of the skin, 1 uterine cancer, and 1 gastric cancer are reported in rats fed with an estrin product obtained from pregnancy urine. A tar cancer is recorded in 1 control rat. Whereas in rats injected with estrone for long periods, carcinoma of the genital tract and breast occurred accompanied by other usual estrin effects, it appears that with prolonged injection of testosterone, the females went into permanent vaginal diestrus, the pituitary weights were not above normal limits, somatic growth was not inhibited, and the predominant neoplastic lesions were fibrous tissue tumors in injected areas, some of which became sarcomatous.
据报道，给喂食从妊娠尿液中提取的雌激素产品的大鼠注射后，出现了3例皮肤焦油癌、1例子宫癌和1例胃癌。1只对照大鼠出现了1例焦油癌。长期注射雌酮的大鼠会发生生殖道和乳腺的癌症，并伴有其他常见的雌激素效应，而长期注射睾酮的雌性大鼠会进入永久性阴道动情后期，垂体重量未超过正常范围，身体生长未受抑制，主要的肿瘤性病变是注射部位的纤维组织肿瘤，其中一些发展为肉瘤。
