Gvozdják A, Borovic F, Bada V, Krutý F, Niederland T R, Gvozdják J
Recent Adv Stud Cardiac Struct Metab. 1975;7:451-7.
The effect of ethanol on the myocardial metabolism of experimental animals was studied in acute and in chronic models. Thirty minutes after intraperitoneal injection of ethanol in a dose of 250 mg/100 gm of body weight there was a significant increase of glycolysis and slight decrease of mitochondrial respiration as well as of respiratory control ratio. No changes were observed in the concentration of high energy phosphates in the heart muscle. The metabolic changes in these acute experiments were of a transitory character; they disappeared parallel with the decline of ethanol level in the blood and in the myocardium. The chronic alcoholic model was observed for 10 weeks. Ethanol (250 mg/100 gm) was injected daily. The analyses of the heart muscle were carried out 24 hr after the last injection of ethanol. In this model ethanol also provoked considerable disturbances of metabolic processes in the myocardium: decrease of glycolysis and of glycogen content, decrease of mitochondrial respiration as well as of respiratory control ratio of isolated mitochondria and decrease of adenosine triphosphate and creatine phosphate with simultaneous increase of inorganic phosphate in the myocardium.
在急性和慢性模型中研究了乙醇对实验动物心肌代谢的影响。以250毫克/100克体重的剂量腹腔注射乙醇30分钟后，糖酵解显著增加，线粒体呼吸以及呼吸控制率略有下降。心肌中高能磷酸盐的浓度未观察到变化。这些急性实验中的代谢变化具有短暂性；它们随着血液和心肌中乙醇水平的下降而消失。对慢性酒精模型观察了10周。每天注射乙醇（250毫克/100克）。在最后一次注射乙醇24小时后对心肌进行分析。在该模型中，乙醇也引起了心肌代谢过程的相当大的紊乱：糖酵解和糖原含量降低，线粒体呼吸以及分离线粒体的呼吸控制率降低，三磷酸腺苷和磷酸肌酸减少，同时心肌中的无机磷酸盐增加。
