de Deckere E A, ten Hoor F
Recent Adv Stud Cardiac Struct Metab. 1975;7:475-83.
The influence of various diets on the coronary flow (Qcor) and oxygen consumption (VO2m) of Langendorff-perfused rat hearts was studied. The diets contained 23 percent of the total amount of calories as proteins and sufficient amounts of minerals and vitamins, while the amounts of starch and type of fat were varied. In the Langendorff set-up, the perfusion pressure (Pp), and/or the developed left ventricular pressure (PD) were varied to change Qcor and VO2m. At Pp = 50 and 90 mm Hg, Qcor and VO2m of the isolated hearts of rats fed 50 percent of the total number of calories (cal%) as sunflower seed oil (50 SSO) or 50 cal% palm oil (50 PO) for 3 days were 10--20 percent higher than those of the hearts of rats fed pellets (11 cal% fat). At Pp = 80 mm Hg and at various levels of PD, Qcor of the isolated hearts of rats fed 50 SSO or 45 PO + 5 SSO for 3 months was about 20 percent higher than that of the isolated hearts of rats fed a high carbohydrate diet. No differences were found in VO2m or in the maximum obtainable value of PD. When rats were fed mixtures (total amount of fat 50 cal%) of SSO and hardened coconut oil (CO) for 3 days, Qcor increased with increasing dietary SSO. The value of Qcor of the isolated hearts of rats fed a high carbohydrate diet containing 5 cal% SSO was in between the values of the groups fed 50 SSO and 45 CO + 5 SSO. Perfusion of the latter two groups of hearts with substrate-free medium increased Qcor by about 35 percent. The total hypoxanthine + inosine output in these two groups of hearts was about 4.0 nmoles-min-1, and remained contstant during perfusion with substrate-free medium. We conclude that the composition of the diet influences the coronary flow of isolated perfused rat hearts. The amount and the type of dietary fat influence both the magnitude and the direction of the effects. The relationship between the type of dietary fat and its effects on coronary flow is complex.
研究了不同饮食对Langendorff灌注大鼠心脏冠脉流量（Qcor）和耗氧量（VO2m）的影响。这些饮食含有占总热量23%的蛋白质以及足量的矿物质和维生素，而淀粉含量和脂肪类型有所不同。在Langendorff装置中，通过改变灌注压力（Pp）和/或左心室舒张末压（PD）来改变Qcor和VO2m。在Pp = 50和90 mmHg时，连续3天摄入占总热量50%（cal%）的葵花籽油（50 SSO）或50 cal%棕榈油（50 PO）的大鼠离体心脏的Qcor和VO2m比摄入颗粒饲料（11 cal%脂肪）的大鼠心脏高10% - 20%。在Pp = 80 mmHg以及不同PD水平下，连续3个月摄入50 SSO或45 PO + 5 SSO的大鼠离体心脏的Qcor比摄入高碳水化合物饮食的大鼠离体心脏高约20%。VO2m或PD的最大可获得值未发现差异。当大鼠连续3天摄入SSO和硬化椰子油（CO）的混合物（总脂肪量50 cal%）时，Qcor随饮食中SSO含量增加而升高。摄入含5 cal% SSO的高碳水化合物饮食的大鼠离体心脏的Qcor值介于摄入50 SSO和45 CO + 5 SSO组之间。用无底物培养基灌注后两组心脏，Qcor增加约35%。这两组心脏中次黄嘌呤 + 肌苷的总输出量约为4.0 nmol·min-1，在用无底物培养基灌注期间保持恒定。我们得出结论，饮食组成会影响离体灌注大鼠心脏的冠脉流量。饮食脂肪的量和类型会影响这种影响的程度和方向。饮食脂肪类型与其对冠脉流量的影响之间的关系很复杂。
