Sensharma G C, Singh S
Acta Anat (Basel). 1975;93(4):534-42. doi: 10.1159/000144531.
Experimental allergic encephalomyelitis (EAE) induced in the rabbit, initially showed inflammatory lesions, followed by demyelination. The EAE lesions also exhibited an ascendency in their appearance, i.e. they involved the spinal cord, brain stem and cerebellum in that order. During the inflammatory stage of EAE, the astrocytes became hypertrophied and the oligodendrocytes were seen to be degenerating. The inflammatory cells included lymphocytes, plasma cells, and gitter cells. When demyelination had set in, there appeared a paucity of oligodendrocytes and a marked astrocytosis in and around the lesions. The relationship of the oligodendrocytes with the maintenance of myelin in the central nervous system is discussed.
在兔子身上诱发的实验性变应性脑脊髓炎（EAE），最初表现为炎症性病变，随后出现脱髓鞘。EAE病变在外观上也呈现出一种上升趋势，即它们依次累及脊髓、脑干和小脑。在EAE的炎症阶段，星形胶质细胞肥大，少突胶质细胞出现退化。炎症细胞包括淋巴细胞、浆细胞和格子细胞。当脱髓鞘发生时，病变内及周围少突胶质细胞数量减少，星形胶质细胞显著增生。文中讨论了少突胶质细胞与中枢神经系统髓鞘维持的关系。
