Terroine T, Delarbre C
Ann Nutr Aliment. 1975;29(1):1-23.
Light, acute vitamin C deficiency or repletion had no uniform effect on lactiodeshydrogenase, each organ reaching specifically (skeletal muscle, heart, kidney, spleen, liver adrenals, testes). There was no correlation with the age of the animal except in the case of testicular lacticodeshydrogenase isoenzymes. Reduction of food intake caracteristic of the late state of scurvy had no effect on the distribution of isoenzymes which was also independent of quantitative variations of enzyme activity. Vitamin C repletion restored the normal distribution of isoenzymes in spleen and liver but not in skeletal muscle. In the last phase of acute vitamin C deficiency, lactiodeshydrogenase activity was generaly elevated (heart and skeletal muscle excepted). When ascorbic acid was given back lacticodeshydrogenase activity remained elevated in liver and spleen but was lowered in skeletal muscle.
轻度、急性维生素C缺乏或补充对乳酸脱氢酶没有一致的影响，每个器官都有特异性变化（骨骼肌、心脏、肾脏、脾脏、肝脏、肾上腺、睾丸）。除了睾丸乳酸脱氢酶同工酶外，与动物年龄没有相关性。坏血病晚期特征性的食物摄入量减少对同工酶的分布没有影响，同工酶分布也与酶活性的定量变化无关。维生素C补充可恢复脾脏和肝脏中同工酶的正常分布，但不能恢复骨骼肌中的正常分布。在急性维生素C缺乏的最后阶段，乳酸脱氢酶活性普遍升高（心脏和骨骼肌除外）。当补充抗坏血酸后，肝脏和脾脏中的乳酸脱氢酶活性仍然升高，但骨骼肌中的活性降低。
