Volkova O V, Nikitin M V, Postnov Iu V
Arkh Patol. 1975;37(9):37-42.
Studies of morphology of the secretory hypothalamo-neurohypophyseal system under conditions of inhibition of the function of the peripheral region of the sympathetic nervous system were carried out. Desympathyzation was achieved by administration to newly born animals of antibodies to the factor of growth of nerves. In addition to the survey histological methods, morphometry, autoradiography and spectrophotometric investigations were also used. The aim of the work was to establish with the help of the methods referred to above the functional state of the hypothalamo-neurohypophyseal secretory system (HNSS) under deep immunological desympathyzation of the organism. The data obtained confirm the existence of a functional connection between the peripheral region of the sympathetic nervous system and HNSS. A hypofunctional state of the sympathetic department caused a rise in the functional activity to HNSS--in supraoptic and paraventricular nuclei of the hypothalamus there were observed enlarged neurones and their nuclei; this was accompanied by an intensification of the biosynthesis processes and secretion of neurosecretory material, neurohypophysis containing lesser amounts of neurosecret than in the norm. The rise of the functional activity of HNSS was accompanied by a higher specific hormonal effect upon the periphery (the effect of the hormone on "target"), which was confirmed by manifestations of working hypertrophy of the medullar of kidneys. The reaction of HNSS was apparently mediated through a complex of pathological changes in the organism and was directed at the maintenance of the optimal tonus of vessels and at preservation of homoestasis as a whole.
开展了在交感神经系统外周区域功能受抑制条件下，对分泌性下丘脑 - 神经垂体系统形态学的研究。通过给新生动物注射抗神经生长因子抗体来实现去交感神经支配。除了常规组织学方法外，还使用了形态测量法、放射自显影法和分光光度法进行研究。这项工作的目的是借助上述方法确定机体深度免疫去交感神经支配状态下，下丘脑 - 神经垂体分泌系统（HNSS）的功能状态。所获数据证实了交感神经系统外周区域与HNSS之间存在功能联系。交感神经部分功能减退状态导致HNSS功能活动增强——在下丘脑视上核和室旁核中观察到神经元及其细胞核增大；这伴随着神经分泌物质生物合成过程及分泌的强化，神经垂体所含神经分泌物质比正常情况下少。HNSS功能活动增强伴随着对外周更高的特异性激素效应（激素对“靶器官”的效应），肾脏髓质工作性肥大的表现证实了这一点。HNSS的反应显然是通过机体一系列病理变化介导的，其目的是维持血管的最佳张力并整体维持内环境稳定。
