Fokin A S, Shutova N T, Lebedeva L N, Klimenko E D
Biull Eksp Biol Med. 1975 May;79(5):28-31.
In a chronic experiment (up to 6 years) on dogs (13) a protracted functional overstrain of the CNS was associated with an additional action changing the hormonal background (castration and mercasolyl injection). A steady hypercholesteremia, atherosclerotic changes in different intraorganic arteries, particularly in the myocardium, developed in dogs; dystrophic processes occurred in the parenchyma of various organs. An important role of functional overstrain of the CNS as one of the leading factors of the "risk" determining the development of disturbances of the regulation of lipid metabolism and formation of the atherosclerotic process in the vessels was demonstrated.
在一项对狗进行的长达6年的慢性实验中（共13只狗），中枢神经系统的长期功能性过度紧张与改变激素背景的额外作用（去势和注射汞撒利）有关。实验狗出现了持续的高胆固醇血症，不同内脏器官的动脉，尤其是心肌，发生了动脉粥样硬化变化；各个器官的实质出现了营养不良性病变。结果表明，中枢神经系统的功能性过度紧张作为“风险”的主要因素之一，在决定脂质代谢调节紊乱以及血管中动脉粥样硬化进程形成方面起着重要作用。
