Ishikawa N, Hagino Y, Shigei T
Jpn J Pharmacol. 1975 Dec;25(6):681-6. doi: 10.1254/jjp.25.681.
Searching for an experimental condition to produce pulmonary edema of uniform high grade severity in rabbits, five different doses of epinephrine (38,60, 100, 160 and 260 mug/ml) were infused at a rate of 0.29 ml/min for 20 min into the femoral vein of fed and fasted animals. Body temperature was maintained at 38 to 40 degrees C. The incidence of pulmonary edema was not dose-dependent, and was approx. 70% by the administration of 60 to 260 mug/ml of epinephrine solutions. In general, the edema was more severe in the fed group than in the fasted. The highest dose of epinephrine was often fatal in the fasted group. One hundred mug/ml (approx. 10 mug/kg/min), fed was regarded as a favourable condition for the experiment. The amounts of lung lipids increased in edema (+) cases of the fed groups. The plasma potassium level was elevated in proportion to the dose of epinephrine. The clotting time of blood was markedly prolonged in edema (+) rabbits. The significance of these observations was discussed in regard to the mechanism of epinephrine-induced pulmonary edema.
为寻找一种能使家兔产生均匀高度严重程度肺水肿的实验条件，将五种不同剂量的肾上腺素（38、60、100、160和260微克/毫升）以0.29毫升/分钟的速度注入进食和禁食动物的股静脉中，持续20分钟。体温维持在38至40摄氏度。肺水肿的发生率与剂量无关，给予60至260微克/毫升肾上腺素溶液时发生率约为70%。一般来说，进食组的水肿比禁食组更严重。最高剂量的肾上腺素在禁食组中常常致命。100微克/毫升（约10微克/千克/分钟），进食状态被认为是该实验的有利条件。进食组水肿（+）病例的肺脂质含量增加。血浆钾水平随肾上腺素剂量的增加而升高。水肿（+）的家兔血液凝固时间明显延长。就肾上腺素诱导肺水肿的机制对这些观察结果的意义进行了讨论。
