Smeyers-Verbeke J, Michotte Y, Pelsmaeckers J, Lowenthal A, Massart D L, Dekegel D, Karcher D
Neurology. 1975 Jan;25(1):48-57. doi: 10.1212/wnl.25.1.48.
Calculi from a case of cerebral idiopathic nonarteriosclerotic calcification (Fahr's disease) were examined. The stone consists of hydroxyapatite and possesses a typical structure: the calcification process seems to be initiated by the formation of small round bodies that are cemented to each other to form the final stone. Calcified vessels are also present, but seem to be a secondary effect. From a comparison with other calcifications, it is concluded that no pathologic significance should be attached to the relatively high levels of trace metals such as zinc, iron, copper, magnesium, lead, and others, with the possible exception of manganese. The organic matrix of the stone contains large quantities of protein. On hydrolysis of this fraction, an important unidentified ninhydrin-positive peak was found. No mucopolysaccharides were found.
对一例脑特发性非动脉硬化性钙化（法尔病）患者的结石进行了检查。结石由羟基磷灰石组成，具有典型结构：钙化过程似乎由小圆形体的形成开始，这些小圆形体相互粘结形成最终的结石。钙化血管也存在，但似乎是继发效应。通过与其他钙化进行比较得出结论，除锰可能例外，对于锌、铁、铜、镁、铅等痕量金属的相对高水平，不应赋予其病理意义。结石的有机基质含有大量蛋白质。对该部分进行水解时，发现一个重要的未鉴定茚三酮阳性峰。未发现粘多糖。
