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[利用尿液薄层色谱法鉴定氨基酸代谢病]

[Identification of aminoacidopathies using thin layer chromatography of urine].

作者信息

Simonetti A B, La Rocca Rossi A

出版信息

Rev Farm Bioquim Univ Sao Paulo. 1975 Jan-Jun;13(1):161-72.

PMID:1228832
Abstract

The aminoacidopathies, inborn errors of aminoacids metabolism, are rare pathological conditions that have mental retardation as secondarty cause. Using TLC with cellulose as adsorvent and using specific solvents and developer, we can obtain early diagnosis of a great number of those biochemical deviations. The authors based themselves in Ersser's publications to effect this research, now in its initial phase. The author's principal aim is to transform the semi-quantitative method into a quantitative one and to early diagnose the metabolic errors of aminoacids.

摘要

氨基酸病,即氨基酸代谢的先天性缺陷,是一种罕见的病理状况,可导致继发性智力发育迟缓。使用以纤维素为吸附剂的薄层色谱法,并使用特定的溶剂和显色剂,我们可以对大量此类生化偏差进行早期诊断。作者以埃尔瑟的出版物为基础进行这项尚处于初始阶段的研究。作者的主要目标是将半定量方法转变为定量方法,并对氨基酸代谢错误进行早期诊断。

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