斑秃、自身免疫与唐氏综合征。
Alopecia areata, autoimmunity, and Down's syndrome.
作者信息
Du Vivier A, Munro D D
出版信息
Br Med J. 1975 Jan 25;1(5951):191-2. doi: 10.1136/bmj.1.5951.191.
Abstract
Alopecia areata occurs more often in Down's syndrome than would be expected by chance, sixty cases being found among 1000 patients with this syndrome compared with one case among 1000 subnormal controls. Because alopecia areata is associated with some organ-specific autoimmune disease and thyroid antibodies are often found in Down's syndrome sera from affected patients were examined for the presence of fluorescent autoantibodies. Antibodies against thyroid components tended to be present in female mongols with alopecia areata in comparison with females in a normal population but not in male mongols. Futhermore, eight out of 23 female mongols (35%) with alopecia areata had antibodies against thyroid components compared with two out of 23 female mongols (9%) without alopecia areata.
摘要
斑秃在唐氏综合征患者中比偶然预期的更为常见，在1000例该综合征患者中发现60例斑秃，而在1000例智力低下的对照者中仅发现1例。由于斑秃与某些器官特异性自身免疫性疾病有关，且唐氏综合征患者血清中常发现甲状腺抗体，因此对患有斑秃的患者进行了荧光自身抗体检测。与正常人群中的女性相比，患有斑秃的蒙古女性倾向于存在针对甲状腺成分的抗体，但男性蒙古人则不然。此外，23例患有斑秃的女性蒙古人中有8例（35%）存在针对甲状腺成分的抗体，而23例无斑秃的女性蒙古人中有2例（9%）存在该抗体。
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