Niimi Y, Iwase S, Fu Q, Kamiya A, Mano T
Department of Autonomic Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Environ Med. 2000 Dec;44(1):56-9.
To elucidate the effect of aging on blood pressure regulation, especially cardiopulmonary baroreflex in humans, we measured the resting value of muscle sympathetic nerve activity (MSNA), heart rate (HR), blood pressure (BP), peripheral venous pressure (PVP), and calf blood flow (CBF) in eight healthy young male subjects and eight healthy aged subjects, and compared the responses to the low level of lower body negative pressure (LBNP) between the two groups. The resting MSNA was higher, and the response of MSNA to LBNP was lower in the aged group than in the young group; the response of PVP to LBNP was also lower in the aged than in the young group. Delta MSNA/delta PVP showed no significant differences between the two groups. The present findings indicate that the effect of LBNP on cardiopulmonary baroreflex is greater in young people than in aged people, but that cardiopulmonary baroreflex may be preserved with advancing age.
为阐明衰老对血压调节的影响，尤其是对人体心肺压力反射的影响，我们测量了8名健康年轻男性受试者和8名健康老年受试者的肌肉交感神经活动（MSNA）、心率（HR）、血压（BP）、外周静脉压（PVP）和小腿血流量（CBF）的静息值，并比较了两组对低水平下体负压（LBNP）的反应。老年组的静息MSNA较高，且MSNA对LBNP的反应低于年轻组；老年组PVP对LBNP的反应也低于年轻组。两组间的ΔMSNA/ΔPVP无显著差异。目前的研究结果表明，LBNP对心肺压力反射的影响在年轻人中比在老年人中更大，但心肺压力反射可能会随着年龄的增长而得以保留。
