Okcu Mehmet Fatih, Goodman Karen J, Carozza Susan E, Weiss Nancy S, Burau Keith D, Bleyer W Archie, Cooper Sharon P
Division of Pediatrics, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Cancer Causes Control. 2002 Sep;13(7):595-602. doi: 10.1023/a:1019555912243.
To investigate the relationship between birth weight and risk of early age childhood cancer and whether racial differences in birth weight distribution could explain differences in the incidence of cancer in white, Hispanic, and black children.
We compared birth weights of 268 children younger than five years old and diagnosed with cancer in the State of Texas in 1995 to the birth weights of 2680 randomly selected, age-matched population-based controls. Birth weight, sex, race/ethnicity, maternal age, smoking status, parity, and gestational age information was ascertained from the birth certificates. Logistic regression analyses were performed to evaluate the association between high birth weight (>4,000 g) and occurrence of childhood cancer.
Increased odds ratios (OR) were found for "total cancer cases" (OR 1.4, 95% CI 0.9-2.1), "leukemia cases" (OR 1.7, 95% CI 0.9-3.0) and "acute lymphoblastic leukemia (ALL) cases" (OR 2.2, 95% CI 1.2-4.1). Increased ORs in the former two groups were shown to be due to ALL cases. Including the race/ethnicity variable in the regression model did not affect the ORs.
Compared to newborns who weighed between 2500 and 4000 g at birth, children who weighed >4,000 g had an increased risk of developing childhood ALL during the first five years of life. Birth weight differences does not explain the sequence of childhood cancer incidence by race/ethnicity.
研究出生体重与儿童早期患癌风险之间的关系,以及出生体重分布的种族差异是否可以解释白人、西班牙裔和黑人儿童癌症发病率的差异。
我们将1995年在德克萨斯州诊断出患有癌症的268名5岁以下儿童的出生体重与2680名随机选择的、年龄匹配的基于人群的对照的出生体重进行了比较。出生体重、性别、种族/族裔、母亲年龄、吸烟状况、产次和孕周信息均从出生证明中获取。进行逻辑回归分析以评估高出生体重(>4000克)与儿童癌症发生之间的关联。
“所有癌症病例”(比值比[OR] 1.4,95%置信区间[CI] 0.9 - 2.1)、“白血病病例”(OR 1.7,95% CI 0.9 - 3.0)和“急性淋巴细胞白血病(ALL)病例”(OR 2.2,95% CI 1.2 - 4.1)的比值比增加。前两组比值比的增加显示是由于ALL病例。在回归模型中纳入种族/族裔变量并未影响比值比。
与出生时体重在2500至4000克之间的新生儿相比,出生体重>4000克的儿童在生命的前五年患儿童ALL的风险增加。出生体重差异并不能解释按种族/族裔划分的儿童癌症发病率顺序。