一种通过三嗪文库正交合成和斑马鱼胚胎筛选得到的新型微管去稳定实体。
A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening.
作者信息
Moon Ho-Sang, Jacobson Eric M, Khersonsky Sonya M, Luzung Michael R, Walsh Daniel P, Xiong Wennan, Lee Jae Wook, Parikh Puja B, Lam Jennifer C, Kang Tae-Wook, Rosania Gustavo R, Schier Alexander F, Chang Young-Tae
机构信息
Department of Chemistry, New York University, New York, NY 10003, USA.
出版信息
J Am Chem Soc. 2002 Oct 2;124(39):11608-9. doi: 10.1021/ja026720i.
PMID:12296721
Abstract
The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.
摘要
首次展示了高纯度三嗪文库的正交组合合成。通过高效的斑马鱼胚胎筛选和体外微管聚合试验发现了新型的基于三嗪的微管抑制剂。
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