氟烷对上皮细胞中钠主动转运的影响。
The effect of halothane on active transport of sodium in the epithelial cell.
作者信息
Szulc R, Knapowski J
出版信息
Anaesth Resusc Intensive Ther. 1975 Oct-Dec;3(4):279-83.
The authors studied the effect of halothane on active transport of sodium in the epithelial cells using the method described by Ussing with frog skin as an experimental model. It was found that the action of the anasthetic agent on the active transport of sodium was biphasic, and this observation confirmed the results obtained with another experimental model. It was observed, moreover, that the mechanism of halothane action on the cell membrane it not identical with that of vasopressin, which was used in some of the present experiments before adding halothane. The present investigations suggest that halothane acts primarily on the cell membrane and not on the deeper situated intracellular structures.
作者采用乌斯辛（Ussing）描述的方法，以蛙皮作为实验模型，研究了氟烷对上皮细胞中钠主动转运的影响。结果发现，麻醉剂对钠主动转运的作用是双相的，这一观察结果证实了在另一个实验模型中获得的结果。此外，还观察到氟烷对细胞膜的作用机制与血管加压素不同，在本实验的一些实验中，在添加氟烷之前使用了血管加压素。目前的研究表明，氟烷主要作用于细胞膜，而不是更深层的细胞内结构。
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