Madej J A, Stańczyk J F
Anaesth Resusc Intensive Ther. 1975 Oct-Dec;3(4):297-303.
The experiments were carried out on 15 dogs and 15 cats of both sexes. All animals received ketamine intramuscularly in doses of 10 mg/kg of body weight (dogs) and 25 mg/kg (cats). After the ketamine injection operations were performed following laparotomy and then the animals were killed by exsanguination 90 min after the injection of ketamine. For histoenzymatic examinations fragments of organs were taken (liver, kidneys, spleen, lungs and heart) and histochemical examinations were done for acid phosphatase (AP), alkaline phosphatase (AIP) and non-specific esterase (NE). It was found that ketamine anaesthesia in dogs and cats causes a slight reversible damage to the liver and kidneys and increases the activity or reticuloendothelial cells in the organism.
实验在15只雌雄兼有的狗和15只猫身上进行。所有动物均接受了氯胺酮肌肉注射，剂量分别为10毫克/千克体重（狗）和25毫克/千克（猫）。注射氯胺酮后，进行剖腹手术，然后在注射氯胺酮90分钟后通过放血处死动物。为进行组织酶学检查，采集了器官碎片（肝脏、肾脏、脾脏、肺和心脏），并对酸性磷酸酶（AP）、碱性磷酸酶（AIP）和非特异性酯酶（NE）进行了组织化学检查。结果发现，氯胺酮麻醉会对狗和猫的肝脏和肾脏造成轻微的可逆性损伤，并增加机体中网状内皮细胞的活性。
