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[医学中正常值的定义]

[Definition of normal values in medicine].

作者信息

Agnese G

出版信息

Arch Sci Med (Torino). 1975 Oct-Dec;132(4):139-50.

PMID:1230134
Abstract

The definition of the normal values of quantitative characters is discussed. Three distinct types of normality: statistical, biological and epidemiological, are examined. A method postulating the presence of several Gaussian components, one of which represents the truly normal population, in a heterogeneous population, is proposed for the statistical analysis of frequency distribution. Examples are given of the application of a relatively simple and effective graphical-numerical process. In the light of the preliminary results, systematic adoption of the process is suggested, not only for the definition of normal values in the sense of biological normality, but also in the comparison of patients and healthy subjects, whereby epidemiological normality can be defined by means of discriminant analysis. Lastly, the possibility of defining normal values for groups of variables is considered.

摘要

本文讨论了定量特征正常值的定义。研究了三种不同类型的正态性:统计学正态性、生物学正态性和流行病学正态性。提出了一种假设在异质群体中存在多个高斯成分的方法,其中一个代表真正的正态总体,用于频率分布的统计分析。给出了一个相对简单有效的图形-数值方法的应用示例。根据初步结果,建议系统采用该方法,不仅用于定义生物学意义上的正常值,还用于患者与健康受试者的比较,从而通过判别分析来定义流行病学正态性。最后,考虑了为变量组定义正常值的可能性。

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