McIntosh G H, Belling G B
Aust J Exp Biol Med Sci. 1975 Dec;53(6):479-87. doi: 10.1038/icb.1975.53.
Intravenously injected 14C labelled oxalate was rapidly removed from the blood stream via the kidney in 2 sheep, 75% being cleared within 8 h. Mean daily urinary oxalate excretions over 5 days were 21-2 and 27-5 mg and the derived plasma oxalate concentrations were 52-6 and 74-4 mug/100 ml, respectively. Oxalate was both filtered and secreted by the renal tubule with oxalate/inulin ratios varying from 1-11 to 1-57 in 6 normal sheep. A large increase in calcium excretion induced by calcium borogluconate infusion over 5 days was accompanied by a small but consistent increase in urinary oxalate excretion relative to calcium. Oxalate in blood was to be found mainly in the plasma, there being a small (8%) proporation within erythrocytes. This is lower than that reported for man, and yet in its excretion of oxalate via the kidney the sheep appears to closely resemble man and dog.
在2只绵羊中，静脉注射的14C标记草酸盐通过肾脏迅速从血流中清除，8小时内75%被清除。5天内平均每日尿草酸盐排泄量分别为21.2毫克和27.5毫克，由此得出的血浆草酸盐浓度分别为52.6微克/100毫升和74.4微克/100毫升。在6只正常绵羊中，草酸盐由肾小管滤过和分泌，草酸盐/菊粉比率在1.11至1.57之间变化。在5天内静脉输注葡萄糖酸钙导致钙排泄大幅增加，同时尿草酸盐排泄相对于钙有小幅但持续的增加。血液中的草酸盐主要存在于血浆中，红细胞内的比例较小（8%）。这低于人类的报道比例，但在通过肾脏排泄草酸盐方面，绵羊似乎与人类和狗非常相似。
